CryostaX® is the largest multi-donor pool available using a single-freeze process, designed to provide long-term consistent results, extensive characterization, the highest possible enzymatic activity, and on-demand custom-pooling.
CryostaX® Pooled Human Hepatocytes for Suspension
XenoTech products are now available for purchase at BioIVT.com!
Browse BioIVT’s hepatocytes, subcellular fractions & recombinant enzymes and create an account on bioivt.com to view pricing, generate quotes, and purchase products. Click here for a guide to the new products’ part numbers.
Your suspension assays are faster and easier when you use CryostaX®
- Patented single-freeze process to minimize cryoinjury
- Simplified thawing procedure
- Enhanced viability and yield
- Extensive characterization
- 10-or 20-donor lots available
- Custom on-demand pooling at no additional charge (use form below)
- Large lots for consistency between assays
- High-quality data
- Up-front pricing
Utilizing CryostaX® Pooled Human Hepatocytes for Suspension
CryostaX® features two different pool sizes, plus custom on-demand options (see form below) based on individual enzyme activities and/or donor demographics from over 200 potential donors. Whatever your study requires, XenoTech can meet your needs with a wide variety of pooled primary human hepatocytes ready for your in-house in vitro work.
Our patented format highlights our commitment to efficiency without sacrifice to quality; CryostaX® hepatocyte pellets go through one cryopreservation cycle rather than two (as is typical of traditional vial format), the thawing process is simplified to enable you to go from storage to assay in fewer steps, and our streamlined ordering process gives you all the information you need–including upfront pricing–to choose the perfect lots for your assays.
Our hepatocyte expertise stems from decades of preparing these test systems for our own contract research. Utilizing the hepatocytes that we produce in our own contract studies allows an added level to quality control beyond the standard characterization that most hepatocytes vendors provide.
Zell Woodworth, Products Division Director at XENOTECH
Simplified Thawing Procedure
With CryostaX®, thawing is easy. Download our thawing protocol or watch the demo to the right to get the best results out of your cryopreserved hepatocytes:
Extensive Characterization
| Enzyme Marker | SUBSTRATE REACTION |
|---|---|
| CYP1A2 | Phenacetin O-dealkylation |
| CYP2B6 | Bupropion hydroxylation |
| CYP2C8 | Amodiaquine N-dealkylation |
| CYP2C9 | Tolbutamide |
| CYP2C19 | S-Mephenytoin 4′-hydroxylation |
| CYP2D6 | Dextromethorphan O-demethylation |
| CYP3A4/5 | Midazolam 1′-hydroxylation |
| UGT | 7-Hydroxycoumarin glucuronidation |
| SULT | 7-Hydroxycoumarin sulfonation |
| OATP1B1 | Esterone sulfate |
| OATB1B3 | CCK-8 |
| OCT1 | MPP+ |
| NTCP | TCA |
On-Demand Custom Pooling
An example of no-charge custom pooling of CryostaX® is shown below. By characterizing each individual donor, XenoTech enables you to pick from an extensive list of available tissue and design your own pools. By using the characterization data it is possible to determine a quick snapshot of the designed pool’s overall activities.
Match your test systems with the right media
Our formulas are optimized to give you the best results from your suspension hepatocytes….
