Author: Michael Millhollen

Since most new drugs fail because of ADME/Tox, you can add considerable value to your compound by conducting early in...

In this month’s installment of our Meet the Scientist series we wanted to feature one of our team of talented...

Over the course of 2021, we expanded access to two important and related study offerings at our US laboratory headquarters....

In this installment of our Meet the Scientist series, we asked several members from various areas of our Program Execution...

This month we’re featuring two of the experts in our analytical services department: Senior Scientist Chandra Kollu and Mass Spectrometry...

With over 3500 respondents, only 4% of respondents said they had never experienced any repercussions from postponing these studies...

In Safety first: Assessing drugs early can preclude regulatory and health issues, a new ebook developed by a collaboration with...

You may have heard about the patented CryostaX® format of hepatocyte pellets, but do you know why XenoTech and countless other researchers have made the…

The 2020 Technology Innovator Awards returns for its fifth year “to reward those talented and dedicated individuals and firms working...

As a global Life Sciences and Healthcare company, XenoTech recognizes the seriousness of the Coronavirus Pandemic. We are constantly monitoring...

At XenoTech, we pride ourselves on our 3S Principles ­– the values and standards that guide our businesses and shape...

Continuing our effort to put faces to the names of some of the scientists you interact with at XenoTech, we...

XenoTech has been named the Best In Vitro Drug CRO in the 2019 Healthcare & Pharmaceutical Awards. From the release:...

Science Exchange stated, “Discovery research programs at growing biotech companies are demanding—R&D leaders must balance the need to innovate with...

XenoTech has been named the Best for Drug Candidate Evaluations 2019 as well as in the Leading Providers of Pharmaceuticals...

XenoTech has been working with and supplying reagents for the pre-clinical ADME field for well over two decades. Years of...

Over the past 25 years of performing ADME/DMPK/DDI contract research, we’ve learned some key strategies to maximize the efficiency and effectiveness...

XenoTech understands that a better future starts with our actions today, and encourages its global family to remain focused on...

On Oct. 15th at the Peptide ADME Discussion Group Workshop in Gothenburg, Sweden, Dr. Brian Ogilvie presented on In vitro Direct and Cytokine-Mediated...

Following XenoTech’s announcement XenoTech Adds Monkey, Rodent Hepatocytes to Patented CryostaX Product Line, Anticipates the End of Traditionally Cryopreserved Hepatocytes, various...

Transporters are membrane-bound proteins that govern the passage of drugs into and out of cells. These gatekeeper proteins can be...

XenoTech has been named the Best Global CRO and was recognized for leadership in Pharmaceutical Safety Testing in the 2018...

In July, Drs. Maciej Czerwinski, Director of Consulting, and Brian Ogilvie, Vice President of Scientific Consulting, submitted XenoTech’s comments in response to the Food...

CryostaX® hepatocytes are created using a patented process that produces unique single-donor cell pellets. This format allows scientists to easily pool primary...

At the 2018 Marbach Castle Drug-Drug Interaction Workshop in Germany, Dr. Brian Ogilvie, Vice President of Scientific Consulting, presented a comparison...

Cryopreservation and thawing of primary hepatocytes causes inherent damage to the cells. Traditional pooling methods require cells to undergo two separate cryopreservation...

XenoTech has patented technology that eliminates the need for the water baths that are traditionally required to thaw cryopreserved hepatocytes. By removing water...

Transporters have become increasingly important in drug development due to the major role they play in absorption, distribution and excretion of...

Following our nomination in late 2017, XenoTech has been named the Best In Vitro Drug Metabolism Studies Provider in the...

Over the past two decades, we’ve received a lot of interesting requests for custom tissue preparations here at XenoTech. “We’ve...

As announced earlier this month, XenoTech has hired a record number of new staff over the past year in order to...

Leader in pharmaceutical research and scientific collaboration Originally printed in the Fall 2017 Issue of NewsWave. XenoTech, LLC, which is...

Updated Nov. 6th, 2017 The FDA has released its long-awaited new draft guidance for industry on drug-drug interaction (DDI) studies....

The clinically-relevant drug-drug interaction (DDI) between the dyslipidemia drug gemfibrozil and the antidiabetic repaglinide is well-documented throughout the literature. In...

At the time of organ recovery, human livers that have been donated for research are flushed with an ice-cold perfusion...

Check out the recent IQ consortium publication: Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from...

The University of Rhode Island College of Pharmacy’s 5th Annual Transporters in Drug Discovery and Development: Driving Knowledge from Laboratory...

Following the promotion of Dr. Joanna Barbara, PhD, to Vice President of Scientific Operations, Dr. Etsuko Usuki, PhD, has been promoted...

XenoTech’s Analytical Services lab provides researchers with custom method development and method validation, dose solution analysis, in vitro and in vivo metabolite profiling studies, small-molecule non-GLP bioanalysis and...

If you have concerns about how your compound may affect UDP-glucuronosyltransferase (UGT) induction and/or inhibition when combined with other therapeutic...

XenoTech is committed to furthering the knowledge surrounding hepatic diseases, which affects one out of four people worldwide, such as...

As you may have heard, XenoTech was issued U.S. Patent No. 9,642,355 for the “CRYOPRESERVATION OF CELLS AND SUBCELLULAR FRACTIONS” for its CryostaX® hepatocytes. The...

XenoTech has appointed Joanna Barbara, Ph.D., as Vice President of Scientific Operations and Brian Ogilvie, Ph.D., as Vice President of Scientific...

Transporters have become increasingly important in drug development due to the major role they play in absorption, distribution and excretion of...

After our nomination in late 2016, XenoTech has been named the Best for Pharmaceutical Safety Testing in the 2017 Biotechnology...

XenoTech is adding human and minipig to the company’s list of species with dermal subcellular fractions available as standard test systems for the development...

For their November/December 2016 issue, Pharmaceutical Outsourcing Magazine interviewed Chris Bohl, PhD, Global Technical Support Manager for XenoTech’s Products Division, on the...

Understand which transporters are involved in a drug’s absorption, distribution & excretion Originally posted on Labiotech.EU How can you build the...

XenoTech scientists published a paper in Drug Metabolism and Disposition evaluating Ketoconazole and its alternative clinical CYP3A4-5 inhibitors as inhibitors of drug...

XenoTech recently fulfilled its largest order of human liver subcellular fractions to date. A large pharmaceutical customer ordered over 30,000...

A Guide to What, Why & When to Conduct ADME Studies When drug developers are preparing their IND, drug metabolism...

What are drug transporters? Drug transporters are membrane-bound proteins that assist in the movement of drugs into or out of...

Over the years, we have received a lot of questions about cytochrome P450 (CYP) 2C induction studies. In February of...

Primary hepatocytes are considered the gold standard for ADME/DMPK studies because they are the most representative in vitro test system. However, not all hepatocyte formats…

Many compounds bind to or diffuse into red blood cells (RBCs), which can significantly impact clearance and cause inaccuracies in PK calculations...

A recap of some of the important and promising research that was presented at the Transporters in Drug Discovery and Development symposium...

Not only can drug transporters affect the absorption and excretion of drugs, they can be involved in pharmacokinetic-based drug-drug interactions...

The Pharmaceutical and BioScience Society (PBSS) hosted the workshop “Drug-Drug Interactions: Update on Risk Assessment, Clinical Evaluation and Regulatory Requirements” on October...

The American Association of Pharmaceutical Scientists (AAPS) and U.S. Food and Drug Administration (FDA) co-sponsored the workshop “Drug Transporters in ADME:...

Leader in pharmaceutical research and scientific collaboration Originally printed in the Fall 2017 Issue of NewsWave. XenoTech, LLC, which is...

The gastrointestinal wall is a significant site of first-pass metabolism for oral drugs, which is commonly associated with CYP450 and...

XenoTech is committed to furthering the knowledge surrounding hepatic diseases, such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis...

Understand which transporters are involved in a drug’s absorption, distribution & excretion Originally posted on Labiotech.EU How can you build the...

XenoTech recently fulfilled its largest order of human liver subcellular fractions to date. A large pharmaceutical customer ordered over 30,000...

On Thursday, April 23rd, XenoTech participated in “bring your child to work day”. At XenoTech, we are passionate about what...