Author: Madison Esely-Kohlman

Repurposing (repositioning, re-profiling, or re-tasking) a drug potentially saves years of costly testing from going to waste and potentially providing a higher chance of success.…

As part of our Meet the Scientist series, we introduce you to one of our most notable product experts, Stephanie Helmstetter.

“Exploring alternative uses for drugs tapped for other indications, can save considerable time and money in discovery, according to an...

As part of our Meet the Scientist series, we introduce you to one of our most notable Enzyme Inhibition experts, Lois Haupt.

We are thrilled to welcome you to the brand new XenoTech website! The reconstruction project is a massive overhaul of over 1,000 pages carefully recrafted…

In preclinical development, a drug will be evaluated for potential to cause a drug-drug interaction (DDI) using in vitro experiments and then calculations that...

The main goal of preclinical toxicokinetic (TK) studies is to establish a correlation between a candidate compound’s concentration or dose...

“Given the rapid spread of COVID-19 and its relatively high mortality, filling the gap for coronavirus-specific drugs is urgent. […]...

Drug metabolism and pharmacokinetics (DMPK) is a core discipline in drug development that considers the biotransformation of a drug compound...

We have welcomed a new consultant to the team! Dr. Pallavi Limaye now serves as a Director in the Scientific...

Highlights from the recent webinar presented by our newest expert consultant, Dr. Pallavi Limaye In her recent webinar (now available for...

We are offering a brand new cell line to assist researchers in the fight against COVID-19.The cell line (JCRB1819), developed...

The main aim of drug development is to get a compound that has a therapeutic effect into the form of...

In its most recent in vitro drug interaction guidance update, the US Food and Drug Administration (FDA) emphasized harmony with the...

1. Collect high-quality data to make informed, confident go/no go decisions for moving your drug candidate forward If you need...

Systemic clearance, denoting how much drug is cleared from a volume of blood per unit of time, is of critical...

Beyond the need for evidence that a drug works, Food and Drug Administration (FDA) and other regulatory bodies around the...

Regulatory authorities publish updated guidance documents that share their expectations for endpoints and test systems with drug developers, but sometimes it is difficult to...

Though there is no ‘roadmap’ spelling out required studies to achieve regulatory approval for clinical entry, a drug candidate’s metabolism...

As a drug moves through the development pipeline, it undergoes a rigorous battery of safety assessments to prove it will...

Because each new drug is unique in characteristics, such as chemical structure, mechanism of action, and physicochemical properties, there can...

Recombinant enzymes represent a useful test system for studies requiring extra high levels of catalytic activity. Due to high customer demand, Cypex has...

We are proud to house some of the brightest minds in this field who have seen “the weird stuff” when...

We’re pleased to announce that our scientists’ ongoing dedication to enhancing our processes and discovering new efficiencies without sacrificing quality...

When putting together a data package for regulatory approval by the FDA, EMA, or PMDA, there is a lot to...

This year at XenoTech we celebrate our 25th birthday, and our partner in Japan turns 64! Looking back over our history,...

Dr. Ogilvie’s presentation discusses critical literature and case studies which have been published following the FDA’s 2017 guidance revision, and covered...

Why do induction studies? Induction potential is an important piece of the drug-drug interaction (DDI) component of an IND submission. Simply put, we...

The Japanese regulatory agent PMDA (Pharmaceuticals and Medical Devices Agency) recently published an official English translation of their final Drug Interaction Guideline...

About JCRB cell bank In addition to focus on preclinical ADME in vitro testing services and complementary products, XenoTech offers to our clients...

While liver and intestine are important in ADME, behavior in blood is also crucial. When an orally administered drug or...

XenoTech is well-known to pharmaceutical companies and toxicology academics alike for unparalleled experience in quality in vitro ADME/DMPK/DDI studies and complementary products,...

As technology evolves to better meet needs in exploration of drug metabolism pathways and disease mechanisms, familiarization with appropriate and...

Agility and focused growth allow drug developers to outsource expertise and benefit the industry at-large by fostering innovation. Panelists at the 2021 Annual DMDG Meeting…

Repurposing (repositioning, re-profiling, or re-tasking) a drug potentially saves years of costly testing from going to waste and potentially providing a higher chance of success.…

“Given the rapid spread of COVID-19 and its relatively high mortality, filling the gap for coronavirus-specific drugs is urgent. […]...

As we begin this summer, many of us are grieving opportunities lost for parties and pool days with friends and...

The main aim of drug development is to get a compound that has a therapeutic effect into the form of...

In vivo determination of drug localization in tissue can be uniquely informative to drug developers investigating distribution within the context of...

In vivo mass balance studies are an important element of nonclinical drug development, to inform first in-human (FIH) studies and to...

Test systems for DMPK in vitro studies are part of the very foundation of our company. Our labs were borne of...

Generally, a drug’s effects on enzyme and transporter activity are examined independently in a drug development program, but what if...

When putting together a data package for regulatory approval by the FDA, EMA, or PMDA, there is a lot to...

Getting reliable, reproducible results from studies using hepatocytes as a model system for drug metabolism is in part dependent on how well...