ADME 101: Lysosomal Trapping
Presenter: Andrew Taylor, Ph.D., Services Technical Support Manager
This ADME 101 video discusses how compounds can become trapped by lysosomes, which can lead to high organ-to-blood ratios and mistaken for active drug transport, how concomitant administration of lysosomotropics could lead to elevated drug exposure levels, and how accumulation of lipophilic amines can lead to drug-induced phospholipidosis due to decreased phospholipid catabolism. This short, information-packed webinar features:
- An overview of lysosomes
- The mechanism of lysosomal trapping
- Lysosomal trapping and drug-drug interactions (DDI)
- Screening and definitive study designs
- Test systems for lysosomal trapping studies
About the presenter: Dr. Andrew G. Taylor received his Ph.D. from University of California San Diego. He joined XenoTech as a research scientist in 2017, serving as a Study Director in nonclinical drug interaction contract studies in compliance with Good Laboratory Practices (GLP), OECD Principles of GLP, &/or Japan MOHW GLP Standards and specializing in drug transport and drug metabolism studies. He became the Technical Support Manager for services in 2020 and provides valuable guidance to ensure research needs are being met.
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