Webinars
Underprediction of Drug Clearance by Aldehyde Oxidase (AO)–Mediated Drug Metabolism: Important Considerations for In Vitro Assessment
Presenter: Pallavi Limaye, Ph.D., DABT, XenoTech Director of Scientific Consulting Abstract: Aldehyde oxidase (AO) enzyme has gained increasing attention in drug development as one of the...
Addressing Unique Challenges with Custom In Vitro Test Systems
Presenter: Zell Woodworth, Division Director of Products at XenoTech Abstract: Sometimes, standard products just don’t fit the objective of a unique assay. In this webinar, Products...
The Role of In Vitro Assays in Selecting the Right Species for Your Small Molecule Program
Presenters: Andrew G. Taylor, Ph.D., Manager of Technical Support for Services at XenoTech and Scott Boley, Ph.D., DABT, Senior Vice President of Research at Sinclair Research...
Red Blood Cell Partitioning Studies to Improve Accuracy in Pharmacokinetics (PK) Calculations
Presenter: Steven McGreal, Ph.D, Study Director at XenoTech Abstract: Pharmacokinetic (PK) parameters of a new drug candidate are typically determined by measuring the drug’s concentration...
An Overview of Non CYP-Mediated Metabolism Pathways and In Vitro Evaluation Strategies
Presenter: Andrew G. Taylor, Ph.D., Technical Support Manager for Services at XenoTech Abstract: Although cytochrome P450 (CYP)-mediated metabolism continues to be of major importance for...
2C or Not 2C: CYP2C Induction Studies for Successful Preclinical Risk Assessment
As a part of IND-enabling preclinical drug development studies companies are required to meet regulatory expectations to evaluate the induction potential of their compound for the cytochrome P450 CYP enzymes CYP1A2, 2B6, 2C8, 2C19 and 3A4. While only CYP1A2, 2B6 and 3A4 must be assessed in the initial induction panel, any observed induction of CYP3A4 requires further investigation of induction potential for enzymes in the CYP2C family due to crosstalk between the PXR and CAR nuclear receptor pathways. This webinar will focus on CYP2C induction and will emphasize when to include CYP2C induction in a study, how to design the study to generate meaningful data and meet the regulatory requirements, what endpoints to measure, and how to interpret results.
In Vitro Cholestatic DILI & Mitochondrial Toxicity Studies to Assess Hepatotoxicity
Drug-Induced Liver Injury (DILI) incidents account for more than 10% of all cases of acute liver failure, posing a major clinical and regulatory challenge. While the cause of DILI is multifactorial and difficult to predict, there are known mechanisms...
ADME 101: Drug Metabolism Studies – Metabolic Stability
Metabolic stability influences the oral bioavailability and plasma half-life of a compound. Metabolic stability assays measure intrinsic clearance and determine the extent to which a drug will be metabolized. This study can be conducted in a variety of test systems, which is why it may also be referred to as a hepatocyte stability study, microsomal stability study...
ADME 101: Model-Based Approaches to DDI Risk Prediction – Navigating the Transition from In Vitro Data to In Silico Modeling
This informative ADME 101 discusses In Vitro to In Vivo Extrapolation (IVIVE) and how a model-based approach following routine perpetrator potential studies (i.e. CYP inhibition, CYP induction, and transporter inhibition) assessing clinical potential may eliminate the need of conducting clinical studies. Listen in as Dr. Limaye outlines a step–wise approach for bringing robustness to the prediction, including...
Suicide by Binding: Putting Time-Dependent Inhibition of CYP Enzymes into Perspective
Presenter: Brian Ogilvie, Ph.D., XenoTech Vice President of Scientific Consulting with special guest for Q&A, Lois Haupt, XenoTech Principal Scientist in Program Oversight Many drug candidates...
What topic would you like to hear about?
Our experts are constantly on the hunt for new and exciting topics to present on, and nothing helps us figure out what you want to hear more than requests and feedback! Use our form to submit your request so we can continue producing educational materials you look forward to
