Scientific Posters

Full Title An in vitro test system to evaluate drug-drug interactions with biologics Authors Maciej Czerwinski1, Christina Renneke2, Joanne Parker2, Chad Pope1, Kevin Lyon1, Catherine...

Full Title Evaluation of dilution, dialysis and ultracentrifugation methods to assess the reversibility of metabolism-dependent inhibitors (MDIs) of cytochrome P450 (CYP) enzymes Abstract Metabolism-dependent inhibition...

Full Title Temporal changes in CYP3A4 mRNA and activity following treatment of cultured human hepatocytes with interleukin-6 (IL-6): Implications for study design and endpoint selection...

Full Title Evaluating the potential for lysosomal trapping in immortalized human hepatocytes (Fa2N-4 cells) Abstract Sequestration of high concentrations of lipophilic amines (a.k.a cationic amphiphilic...

Sequestration of high concentrations of lipophilic amines (a.k.a cationic amphiphilic drugs or CADs) in the acidic (pH 4-5) environment of lysosomes contributes to their presystemic clearance.

Cryopreserved hepatocytes provide a convenient in vitro test system to study the phase-1 and phase-2 metabolism of new chemical entities; however cryopreservation (freeze-thaw cycles) can...

Full Title Accurate mass spectrometry elucidates a misleading metabonate formed from amine-containing drugs in reactive metabolite screening assays Abstract The propensity of drug candidates to...

In vitro inhibition and induction ofHuman liver cytochrome P450 enzymes by NTBC and its metabolism in human liver microsomes 2-(2-Nitro-4-trifluoromethylbenzoyl)-1, 3-cyclohexanedione (NTBC, also known as...

Full Title In situ evaluation of CYP1A2, CYP2B6 and CYP3A4/5 induction in cultured human hepatocytes with a cocktail of probe substrates: A comparison of percent...

Full Title Identification of a novel carbamoyl glucuronide as a metabolism-dependent inhibitior of CYP2C8 Abstract Glucuronidation is a major route of drug biotransformation and detoxification,...