Scientific Posters

Full Title Time-course of Cytochrome P450 (CYP450) induction in cultured human hepatocytes: Evaluation of activity and mRNA expression profiles for six inducible CYP450 enzymes Abstract...

Full Title Comparison of Ki and IC50 values for prototypical and clinically-relevant probe substrates of the hepatic transporters OATP1B1 and OATP1B3 Abstract Organic anion transporting polypeptides 1B1...

Full Title Test system-dependent clearance of CYP2D6 and CYP3A4/5 substrates: A comparison of human liver microsomes and cryopreserved human hepatocytes Abstract The in vitro to...

Full Title Selection of human liver S9 and cytosol fractions for evaluating clearance by aldehyde oxidase (AO): The impact of low versus high AO activity lots. Abstract Aldehyde oxidase...

Full Title System-dependent inhibition of BCRP transport by high- and low-permeable compounds in bi-directional MDCKII cells and membrane vesicles Abstract Breast cancer resistance protein (BCRP,...

This poster was presented at the annual AAPS conference in 2013 Full Title Comparison of IC50 Values for Prototypical and Clinically-Relevant Probe Substrates and Inhibitors...

This poster was presented at the annual AAPS conference in 2013. Full Title Comparison of Ki and IC50 Values for Prototypical Inhibitors of Uptake Transporters...

Full Title Esomeprazole, omeprazole sulfone, 5-O-desmethyl omeprazole and 5-hydroxylansoprazole are in vitro metabolism-dependent inhibitors of CYP2C19 Abstract The intensively researched interaction between clopidogrel and proton...

Full Title Can Ki values for direct inhibition of CYP enzymes be reliably estimated from IC50 values? Abstract Regulatory agencies recommend that the potential for...

Full Title A robust method to identify compounds that undergo intracellular lysosomal sequestration Abstract Lysosomes are acidic organelles (pH 4-5) that play a key role...