Scientific Posters

Full Title Exploring the Drug-Drug Interaction Between Gemfibrozil and Repaglinide in Rats: Metabolism and Transport Abstract A clinically-relevant drug-drug interaction (DDI) between the dyslipidemia drug gemfibrozil...

Full Title The Use of Pooled Plated Cryopreserved Human Hepatocytes for the Determination of Metabolic Clearance, CYP Induction, and Uptake Transporter Studies Abstract During early...

Full Title Induction of UDP-Glucuronosyltransferases in Cultures of Fresh and Immortalized Human Hepatocytes Abstract We have examined the induction of UDP-glucuronosyltransferases (UGTs) in primary cultures...

Full Title Determination of Low Intrinsic Clearance Values using Primary Human Hepatocytes and the HepaRG® Cell Line – A Comparison of Methods Svanberg, et al...

Full Title High content automated metabolic stability and CYP inhibition cocktail screening assays for early drug development Abstract The assessment of metabolic stability and cytochrome...

Full Title Human liver S9 fractions stored at -70°C maintain high phase I and phase II enzymatic activities over multiple freeze/thaw cycles and for at...

Full Title High-resolution mass spectrometry for rapid metabolite characterization and reaction phenotyping: a case study with repaglinide Abstract Assessing the involvement of specific cytochrome P450...

Full Title Midazolam clearance in human hepatocytes is restricted compared with human liver microsomes but not by cell permeability or cofactor availability Abstract In our...

Full Title Substrate-Specific Inactivation of CYP3A by the HIV Protease Inhibitors Ritonavir, Saquinavir and Amprenavir Abstract HIV protease inhibitors (PIs), such as ritonavir, saquinavir, and...

Full Title Endotoxin up-regulates the proinflammatory cytokines TNF-α and IL-6 in freshly-isolated human Kupffer cells Abstract Kupffer cells, macrophages endogenous to the liver, can modulate...