Scientific Posters
Evaluation of BSEP Inhibitors Using B-CLEAR® Human Hepatocytes to Predict Inhibition and Cholestasis
Full Title Evaluation of BSEP Inhibitors Using B-CLEAR® Human Hepatocytes to Predict Inhibition and Cholestasis Abstract Drug-induced liver injury (DILI) is characterized as liver injury...
Comparison of Ki and IC50 Values for Prototypical Inhibitors of ABC Transporters P-gp and BCRP
Full Title Comparison of Ki and IC50 Values for Prototypical Inhibitors of ABC Transporters P-gp and BCRP Abstract Ki values were determined for prototypical inhibitors...
Accumulation of Taurocholic Acid in B-CLEAR® Human Sandwich-Cultured Hepatocytes in the Presence of Clinically Relevant Cholestatic Agents
Full Title Accumulation of Taurocholic Acid in B-CLEAR® Human Sandwich-Cultured Hepatocytes in the Presence of Clinically Relevant Cholestatic Agents Abstract Drug induced liver injury (DILI)...
Automated Plasma Protein Binding Using Rapid Equilibrium Dialysis
Full Title Automated Plasma Protein Binding Using Rapid Equilibrium Dialysis Abstract A pharmacokinetic/pharmacodynamic principle important in drug development is that it is the free (unbound)...
Rapid mRNA Induction Screen
Full Title A Rapid High Content Cytochrome P450 (CYP) mRNA Induction Screen for Early Drug Development Abstract Cytochrome P450 (CYP) enzymes play an important role...
Effects of Various Media on the In Vitro Metabolism of Cytochrome P450 Substrates
Full Title The Effect of Buffer Ionic Strength or Various Media on the In Vitro Metabolism of Cytochrome P450 Substrates in Pooled Human Liver Microsomes...
Assessment Under Initial Rate Conditions of the Selectivity and Time Course of Cytochrome P450 Inactivation in Pooled Human Liver Microsomes and Hepatocytes
Full Title Assessment Under Initial Rate Conditions of the Selectivity and Time Course of Cytochrome P450 Inactivation in Pooled Human Liver Microsomes and Hepatocytes: Optimization...
Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Major Drug Uptake Transporters
Full Title Comparison of Ki and IC50 Values for Prototypical Inhibitors of the Major Drug Uptake Transporters Abstract We previously reported on the similarities and...
In Vitro System-Dependent Inhibition of CYPs, UGTs, and Drug Transporters by Oligonucleotides
Full Title In Vitro System-Dependent Inhibition of CYPs, UGTs, and Drug Transporters by Oligonucleotides Abstract We previously examined the cytochrome P450 (CYP) inhibition potential of...
The Impact of Incomplete Dose-Response Curves on EC50 and Emax Determinations in Enzyme Induction
Full Title The Impact of Incomplete Dose-Response Curves on EC50 and Emax Determinations in Enzyme Induction Assessment Abstract In evaluating the enzyme induction potential of...