Scientific Posters
CYP1A2 enzyme localization in normal and diseased pediatric livers
Presented at the 55th Congress of European Societies of Toxicology (EUROTOX 2019) in Helsinki, Finland Full Poster Title “CYP1A2 Enzyme Activity and Protein Abundance In Normal...
Human mAb stability and cytotoxicity in rat hepatocytes with a surrogate peptide approach
Evaluating stability and cytotoxicity of human monoclonal antibody in cultured rat hepatocytes with a surrogate peptide approach Presented at the 12th International ISSX Meeting in Portland...
Human monoclonal antibody stability in rat cell cultures using surrogate peptide LC-MS/MS
Evaluating stability of human monoclonal antibody in rat cell cultures using a surrogate peptide LC-MS/MS approach Presented at the 67th ASMS Conference on Mass Spectrometry &...
An assessment of in vitro inhibition of CYPs, UGTs and transporters by phosphodiester- or phosphorothioate-linked oligonucleotides
Full Title An assessment of in vitro inhibition of CYPs, UGTs and transporters by phosphodiester- or phosphorothioate-linked oligonucleotides Presented at the 2019 Marbach Castle Drug-Drug...
Patterns of hyaluronan deposition in normal and diseased pediatric livers
Full Title Patterns of hyaluronan deposition in normal and diseased pediatric livers Authors Maciej Czerwiński1, Alexander Kats2, Jordan Surgnier3, Sarah E. Tague4, and Michele T....
Alcohol consumption uniquely increases hepatic hyaluronan content in patients with liver steatosis
Full Title Alcohol consumption uniquely increases hepatic hyaluronan content in patients with liver steatosis Authors Dr. Maciej Czerwinski1, Jordan Surgnier2, Dr. Sarah E. Tague3 and...
Cytokine-mediated suppression of CYP enzymes by a toll-like receptor 9 agonist in hepatocytes
Presented at the American college of Toxicology (ACT) 39th Annual Meeting in Palm Beach, FL Full Title “Cytokine-mediated suppression of CYP enzymes by the toll-like...
Ultrasensitive quantitation assay of oligonucleotide therapeutics based on the PALSAR method
Full Title Ultrasensitive quantitation assay of oligonucleotide therapeutics based on the PALSAR method Abstract Recently, development of oligonucleotide therapeutics has accelerated in the pharmaceutical industry,...
Inhibitory effect of typical CYP inhibitors under long term incubation in human liver microsomes
Full Title Inhibitory effect of typical CYP inhibitors under long term incubation in human liver microsomes Authors Sho Nishinoaki, Ryo Fujino, Kenta Hashizume, Tsutomu Negama...
Microsomal cytochrome P450 (CYP) enzyme activities in nonalcoholic steatohepatitis (NASH) livers
Full Title Pitfalls in the Design of Metabolism-Dependent CYP Inhibition (MDI) Experiments With a Dilution Step: Inhibitor Depletion by Metabolism and/or Microsomal Binding Leads to...