Publications
Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 cells)
Kazmi F, Hensley T, Pope C, Funk RS, Loewen GJ, Buckley DB, Parkinson A Lipophilic (logP > 1) and amphiphilic drugs (also known as cationic...
High-Resolution Mass Spectrometry Elucidates Metabonate (False Metabolite) Formation from Alkylamine Drugs During In Vitro Metabolite Profiling
Presented by: Barbara JE, Kazmi F, Muranjan S, Toren PC, Parkinson A In vitro metabolite profiling and characterization experiments are widely employed in early drug...
Catechol and aldehyde moieties of 3,4-dihydroxyphenylacetaldehyde contribute to tyrosine hydroxylase inhibition and neurotoxicity
Lydia M. Vermeer , Virginia R. Florang , Jonathan A. Doorn Parkinson’s disease (PD) is a progressive neurodegenerative disorder which leads to the selective loss...
Activator Protein-1 Regulation of Murine Aldehyde Dehydrogenase 1a1
Previously we demonstrated that aldehyde dehydrogenase (ALDH) 1a1 is the major ALDH expressed in mouse liver and is an effective catalyst in metabolism of lipid aldehydes...
2012 FDA Draft Guidance, “Drug Interaction Studies — Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations”
FDA 2012, Drug Interaction Studies- Study Design, Data Analysis, Implications for Dosing and Labeling Recommendations – DRAFT GUIDANCE Download Publication
Use of enzyme inhibitors to evaluate the conversion pathways of ester and amide prodrugs: A case study example with the prodrug ceftobiprole medocaril
Gary Eichenbaum, Jennifer Skibbe, Andrew Parkinson, Mark D. Johnson, Dawn Baumgardner, Brian Ogilvie, Etsuko Usuki, Fred Tonelli, Jeff Holsapple and Anne Schmitt-Hoffmann An approach was...
An Evaluation of the Dilution Method for Identifying Metabolism-Dependent Inhibitors of Cytochrome P450 Enzymes
Andrew Parkinson, Faraz Kazmi, David B. Buckley, Phyllis Yerino, Brandy L. Paris, Jeff Holsapple, Paul Toren, Steve M. Otradovec and Brian W. Ogilvie Abstract Metabolism-dependent...
The Proton Pump Inhibitor, Omeprazole, but Not Lansoprazole or Pantoprazole, Is a Metabolism-Dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel
Ogilvie BW, Yerino P, Kazmi F, Buckley DB, Rostami-Hodjegan A, Paris BL, Toren P, Parkinson A As a direct-acting inhibitor of CYP2C19 in vitro, lansoprazole...
Comprehensive Quantitative and Qualitative Liquid Chromatography–Radioisotope–Mass Spectrometry Analysis for Safety Testing of Tolbutamide Metabolites Without Standard Samples
Zenzaburo Tozuka, Shinsuke Aoyama, Kohei Nozawa, Shoji Akita, Toshinari Oh-Hara, Yasuhisa Adachi, Shin-Ichi Ninomiya ADME & Tox. Research Institute, SEKISUI Medical Company, Ltd., Tokai, Ibaraki...
2010 EMA Draft Guideline, “Guideline on the Investigation of Drug Interactions”
The European Medicines Agency released their “Guideline to the Investigation of Drug Interactions” draft guidance on April 22, 2010. Download Publication