As test systems become introduced and subsequently vetted by CROs and the scientific community for value and utility in quality, predictive assays, we compile relevant studies and research relating to those which are commonly used or suggested by regulatory authorities for in-house testing. To view our available test systems and reagents, visit our DMPK Test Systems page.
Plateable hepatocytes are often used for induction studies and to research metabolism, biochemistry, virology, host/pathogen interactions, and cell biology. Here,...
Primary hepatocytes are considered the gold standard for ADME/DMPK studies because they are the most representative in vitro test system. However, not all hepatocyte formats…
Many compounds bind to or diffuse into red blood cells (RBCs), which can significantly impact clearance and cause inaccuracies in PK calculations...
MicroPhysiological Systems (MPS) is a general term used to describe miniaturized, in vitro test systems that couple microfluidics with advanced...
You may have heard about the patented CryostaX® format of hepatocyte pellets, but do you know why XenoTech and countless other researchers have made the…
As part of our Meet the Scientist series, we introduce you to one of our most notable product experts, Stephanie Helmstetter.
In preclinical development, a drug will be evaluated for potential to cause a drug-drug interaction (DDI) using in vitro experiments and then calculations that...
The main goal of preclinical toxicokinetic (TK) studies is to establish a correlation between a candidate compound’s concentration or dose...
We are offering a brand new cell line to assist researchers in the fight against COVID-19.The cell line (JCRB1819), developed...
Test systems for DMPK in vitro studies are part of the very foundation of our company. Our labs were borne of...
Recombinant enzymes represent a useful test system for studies requiring extra high levels of catalytic activity. Due to high customer demand, Cypex has...
Getting reliable, reproducible results from studies using hepatocytes as a model system for drug metabolism is in part dependent on how well...
About JCRB cell bank In addition to focus on preclinical ADME in vitro testing services and complementary products, XenoTech offers to our clients...
While liver and intestine are important in ADME, behavior in blood is also crucial. When an orally administered drug or...
XenoTech has been working with and supplying reagents for the pre-clinical ADME field for well over two decades. Years of...
Not only can drug transporters affect the absorption and excretion of drugs, they can be involved in pharmacokinetic-based drug-drug interactions...
That is the question. . . Knowing the answer may save you time and money Good Laboratory Practices (GLP) are...
As a distributor for Cypex in the US and Canada, XenoTech is proud to offer this portfolio of products based on patented...
Following XenoTech’s announcement XenoTech Adds Monkey, Rodent Hepatocytes to Patented CryostaX Product Line, Anticipates the End of Traditionally Cryopreserved Hepatocytes, various...
CryostaX® hepatocytes are created using a patented process that produces unique single-donor cell pellets. This format allows scientists to easily pool primary...
Originally published in tebu-bio’s Being Bioreactive. To purchase XenoTech’s products in the EU, please visit tebu-bio’s website. NADPH is a critical cofactor...
Cryopreservation and thawing of primary hepatocytes causes inherent damage to the cells. Traditional pooling methods require cells to undergo two separate cryopreservation...
Originally published in tebu-bio’s Being Bioreactive. To purchase XenoTech’s products in the EU, please visit tebu-bio’s website. Following up on my series...
XenoTech has patented technology that eliminates the need for the water baths that are traditionally required to thaw cryopreserved hepatocytes. By removing water...
Choosing the most suitable small animal model is crucial for pharmacokinetic and/or toxicology studies in order to get usable, relevant data. Due to potential...
Originally published in tebu-bio’s Being Bioreactive. To purchase recombinant CYPs in the EU, please visit tebu-bio’s website. For North American orders, please follow...
Over the past two decades, we’ve received a lot of interesting requests for custom tissue preparations here at XenoTech. “We’ve...
Compounds that exhibit high metabolic stability in hepatocytes and subcellular fractions (S9, microsomes and cytosol) can be a challenge for ADME scientists. These in...
Pooled human hepatocytes can complement a selection of hepatocytes from various species for metabolite profiling, species comparison and evaluation of potential human-specific metabolites. HepatoSure® is the...
At the time of organ recovery, human livers that have been donated for research are flushed with an ice-cold perfusion...
The gastrointestinal wall is a significant site of first-pass metabolism for oral drugs, which is commonly associated with CYP450 and...
If you are looking for enzymatic in vitro tools for drug metabolism, reaction phenotyping or metabolite generation using a pig model, you may find these newly...
XenoTech is committed to furthering the knowledge surrounding hepatic diseases, which affects one out of four people worldwide, such as...
As you may have heard, XenoTech was issued U.S. Patent No. 9,642,355 for the “CRYOPRESERVATION OF CELLS AND SUBCELLULAR FRACTIONS” for its CryostaX® hepatocytes. The...
XenoTech is adding human and minipig to the company’s list of species with dermal subcellular fractions available as standard test systems for the development...
Before releasing these test systems, there was not a high quality, specific, relevant, easy and ready to use, in vitro test system to...