Drug metabolism studies profile metabolic pathways and likely metabolites formed by a compound, as well as identify drug-metabolizing enzymes involved in its biotransformation. For more information about these services, visit our Drug Metabolism contract studies page.
A Guide to What, Why & When to Conduct ADME Studies When drug developers are preparing their IND, drug metabolism...
Since most new drugs fail because of ADME/Tox, you can add considerable value to your compound by conducting early in...
Many compounds bind to or diffuse into red blood cells (RBCs), which can significantly impact clearance and cause inaccuracies in PK calculations...
Over the course of 2021, we expanded access to two important and related study offerings at our US laboratory headquarters....
With over 3500 respondents, only 4% of respondents said they had never experienced any repercussions from postponing these studies...
Agility and focused growth allow drug developers to outsource expertise and benefit the industry at-large by fostering innovation. Panelists at the 2021 Annual DMDG Meeting…
Drug metabolism and pharmacokinetics (DMPK) is a core discipline in drug development that considers the biotransformation of a drug compound...
Highlights from the recent webinar presented by our newest expert consultant, Dr. Pallavi Limaye In her recent webinar (now available for...
The main aim of drug development is to get a compound that has a therapeutic effect into the form of...
1. Collect high-quality data to make informed, confident go/no go decisions for moving your drug candidate forward If you need...
Systemic clearance, denoting how much drug is cleared from a volume of blood per unit of time, is of critical...
Beyond the need for evidence that a drug works, Food and Drug Administration (FDA) and other regulatory bodies around the...
Regulatory authorities publish updated guidance documents that share their expectations for endpoints and test systems with drug developers, but sometimes it is difficult to...
Though there is no ‘roadmap’ spelling out required studies to achieve regulatory approval for clinical entry, a drug candidate’s metabolism...
Test systems for DMPK in vitro studies are part of the very foundation of our company. Our labs were borne of...
Generally, a drug’s effects on enzyme and transporter activity are examined independently in a drug development program, but what if...
Why do induction studies? Induction potential is an important piece of the drug-drug interaction (DDI) component of an IND submission. Simply put, we...
That is the question. . . Knowing the answer may save you time and money Good Laboratory Practices (GLP) are...
Originally published in tebu-bio’s Being Bioreactive. To purchase XenoTech’s products in the EU, please visit tebu-bio’s website. NADPH is a critical cofactor...
Cryopreservation and thawing of primary hepatocytes causes inherent damage to the cells. Traditional pooling methods require cells to undergo two separate cryopreservation...
Originally published in tebu-bio’s Being Bioreactive. To purchase recombinant CYPs in the EU, please visit tebu-bio’s website. For North American orders, please follow...
Compounds that exhibit high metabolic stability in hepatocytes and subcellular fractions (S9, microsomes and cytosol) can be a challenge for ADME scientists. These in...
Pooled human hepatocytes can complement a selection of hepatocytes from various species for metabolite profiling, species comparison and evaluation of potential human-specific metabolites. HepatoSure® is the...
At the time of organ recovery, human livers that have been donated for research are flushed with an ice-cold perfusion...
The gastrointestinal wall is a significant site of first-pass metabolism for oral drugs, which is commonly associated with CYP450 and...