Patterns of hyaluronan deposition in normal and diseased pediatric livers

Scientific Resources Patterns of hyaluronan deposition in normal and diseased pediatric livers

• Published on March 13, 2019
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Full Title

Patterns of hyaluronan deposition in normal and diseased pediatric livers

Authors

Maciej Czerwiński¹, Alexander Kats², Jordan Surgnier³, Sarah E. Tague⁴, and Michele T. Pritchard^3,5

¹XenoTech, Kansas City, KS., ²Department of Pathology and Laboratory Medicine, Children’s Mercy Hospital, Kansas City, MO., ³Department of Pharmacology, Toxicology and Therapeutics, ⁴Kansas Intellectual and Developmental Disabilities Research Center, ⁵The Liver Center, University of Kansas Medical Center, Kansas City, KS

Abstract

The incidence of obesity and non-alcoholic fatty liver disease (NAFLD) is growing in children. Hyaluronan (HA), an extracellular matrix (ECM) glycosaminoglycan, is increased in liver and blood from adults with advanced liver disease. HA accumulation is also associated with inflammation and fibrosis in extrahepatic tissues. HA levels have not been examined in healthy or diseased livers from pediatric patients. Here, we sought to determine if hepatic HA deposition was associated with donor age and/or disease by using a pediatric liver tissue microarray (TMA)…

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